Here's a recent article again about the read-option.
It only tells what anybody who has studied the offense already knows, but I like how Saban has "crystalized" what needs to be done...in it he says...
“People getting up the field to pass rush is what it’s all about <in NFL> because of the type of quarterbacks — the Tom Bradys of the world, Drew Brees, that’s what you’ve got to stop. You’ve got to put pressure on the quarterback. Well, that’s just what you don’t want to do against [read-option quarterbacks]. You have to play on the line of scrimmage just like old option football.”
The read-option isn't anything revolutionary in terms of scheme, but takes advantage of an athletic QB, or more accurately, the skills that they have.
My take is...Force these QB's to think, or use their minds in making plays. Focus on stopping the run, and containing the pocket, and make them beat you with their arm. Of the 3 newly minted read-option QB's, only RGIII has got both high level brains and physicality. Don't give them an out by allowing them to run. You notice this a lot with rookie QB's...when they get in trouble they take off running, but these 3 can run the ball well, perhaps even better than they throw it. Make them throw it 30-40 times in a game. I suspect defenses twill get their fair share of turnovers. Defenses need to play with discipline, discipline, and more discipline.