Tom Brady - Let's face it, if you have Brady on your roster he is going to be your man. This advice is more for the folks who play in weekly leagues, such as the ones at FanDuel. This would be a good time to take the cap hit and invest in the New England quarterback. Why? Tom is on a hot streak right now and he is headed into a Brady vs Luck aerial circus. Tha Colts were lit up by Ben Roethleisberger a couple weeks ago when he turned in a six TD performance. If Big Ben is good for six scores, how many is Brady capable of?
Philip Rivers - The Chargers QB has been a consistent fantasy performer this season, and this week he has an opportunity to take on a Raiders secondary that he has already torched once this season. This time around the Raiders could be without their top corner, D. J. Hayden, who suffered a groin injury last weekend.
Matt Ryan - Matty Ice is a risk/reward gamble that could be worth taking. This week he will be facing a Carolina Panthers defense that was embarrassed bu Mark Sanchez on Monday night. The Ice man flows hot and cold, but if he is hot against Carolina, he will make fantasy owners very happy.
Mark Sanchez - One week against a struggling defense does not mark a revitalization of the Butt Fumble QB's career. Chip Kelly's offensive scheme may be quarterback friendly, but the Green Bay defense Sanchez faces this weekend will not be. Welcome back to the NFL, Mr. Sanchez.
Jay Cutler - The Chicago passer will try to operate behind a offensive line that has looked like a turnstile recently. Their opponents, the Minnesota Vikings, only do a few things well, but one of those is rushing the passer. They also do a good job of holding opposing QBs to under 20 point performances. Things do not look up for Cutler this weekend.
Frank Gore - The New York Giants rank last in the NFL in rush defense, so you probably want to start whomever runs the ball for their opponents. This week that happens to be some guy named Frank Gore. You might have heard of him.
Mark Ingram - The Bengals run defense is almost as bad as the one in New York. Mark Ingram will look to cash in on that opportunity and rush for his fourth consecutive 100 yard game. Last week he went for 120 against a tough 49ers D. This week he should have a much better performance against Cincinnati.
Le'Veon Bell - Bell is another back who finds himself in a position to take advantage of the opportunity to exploit a terrible run defense. The Tennessee Titans defense is not quite as weak as the ones in New York and Cincinnati are, but given time they could reach that point. Bell will make a significant contribution to help them get there.
Reggie Bush - Theo Riddick is taking snaps away from Bush of late, and the veteran back's health issues are not helping his cause. Ankle tweeks are limiting his usefulness. A tough Arizona rush defense will compound the issues that both Lions runners face this weekend.
St. Louis RB's - Jeff Fisher's RB by committee philosophy precludes any one back putting up top tier numbers, but Tre Mason is currently the big dog in this backfield. None of this really matters this weekend. the Denver Broncos have the best run defense in the league, and they will shut down whomever carries the ball for the Rams.
DeSean Jackson - DJax has went over the 100 yard mark five times this season, which ranks him second in the NFL for 100 yard games by WRs. He should make it six times this weekend since the Skins face a Tampa Bay defense that surrenders 100 yard efforts more freely than Lovie Smith would appreciate. They also allow more fantasy points than any other team.
Kelvin Benjamin - The Atlanta Falcons pass defense is atrocious. If Cam Newton and his under-performing offensive line can stand up to the pass rush long enough for the ball to be thrown his way, Benjamin should be able to take advantage of the weak opposition he will face.
Anquon Boldin - Boldin should find himself facing Jayron Hosley this weekend. Opposing slot receivers have consistently picked on Hosley this year. The SF receiver is better than most, and he should cash in big time. If Frank Gore can start gashing the Giants on the ground, it should help create even more chances to Colin Kaepernick to mix things up and get the ball into Boldin's hands.
Larry Fitzgerald - Fitzgerald and Carson Palmer were really finding a groove, but now Palmer is gome. Back up QB Drew Stanton does not have nearly the same chemistry with the Cards top receiver, and the offense will suffer for that.
Marques Colston - Of late, Brew Brees has not been looking Colston's way. Even if he did, it might not make any difference. The Bengals secondary, especially their cornerbacks, are a tough match up for opposing passing games.
Jared Cook - The one weak sport in Denver's defense is an inability to stop opposing tight ends. For St. Louis, Cook may be the only effective tool in the shed this weekend. If they can get the ball into Jared's hands, he should be able to do more than his share of damage. It will not be enough for the Rams, but it could make the difference in your fantasy match-up.
Mychal Rivera - Rivera went on a short run of top notch production for the silver and black, but that run appears to be coming to an end. He was shut down last week, and his prospects against the Chargers do not look good. San Diego is one of the better defenses against the position.
Editor's Note: FanDuel is hosting a one-week $500,000 fantasy football league this weekend. It's $10 to join and first place wins $40,000. League starts Sunday 1 PM ET and ends on Monday night. Here's the link.